Article
Association of the toll-like receptor 9 gene polymorphisms with Behcet's disease in a Japanese population.
Fukushima journal of medical science - 1 Jan 2012
Sakamoto Natsumi, Sekine Hideharu, Kobayashi Hiroko, Sato Yukio, Ohira Hiromasa
Abstract excerpt
Bacterial infection (i.e., Streptococcus sanguinis) has been suggested to be related to pathogenesis and/or symptom of Behcet's disease (BD). Toll-like receptor 9 (TLR9) plays an important role in both the innate and adaptive immune systems by recognizing a component of bacterial DNA (i.e., CpG-DNA). Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in TLR9 were associated with...
Topics
- Adult
- Aged
- Arthritis, Rheumatoid
- Asian People
- Behcet Syndrome
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Homozygote
- Humans
- Japan
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Toll-Like Receptor 9
- Young Adult