Article
Association analysis of Toll-like receptor 7 gene polymorphisms and Behçet's disease in Japanese patients.
Human immunology - 1 Mar 2011
Sada Toshiro, Ota Masao, Katsuyama Yoshihiko, Meguro Akira, Nomura Eiichi, Uemoto Riyo, Nishide Tadayuki, Okada Eiichi, Ohno Shigeaki, Inoko Hidetoshi, Mizuki Nobuhisa
Abstract excerpt
Action of Toll-like receptors (TLRs) is deeply associated with defense mechanisms of the innate and adaptive immune responses to microbial pathogens. There have been reports of genetic polymorphisms within the TLR7 gene being closely related to a variety of inflammatory and infectious diseases. Behçet's disease (BD) is an autoinflammatory disease, and the pathogenesis has yet to be fully discovered. We...
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