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Article

Frequent Fas gene mutations in testicular germ cell tumors.

The American journal of pathology - 1 Aug 2002

Takayama Hitoshi, Takakuwa Tetsuya, Tsujimoto Yuichi, Tani Yoichi, Nonomura Norio, Okuyama Akihiko, Nagata Shigekazu, Aozasa Katsuyuki

Abstract excerpt

The Fas (Apo-1/CD95)/Fas ligand (L) system is involved in cell death signaling, and has been suggested to be important for the regulation of germ cell apoptosis in the testis. Mutations of the Fas gene may result in accumulation of germ cells and thus might contribute to testicular carcinogenesis. The open reading frame of Fas cDNA was examined in 24 cases of testicular germ cell tumors (TGCTs), comprised of 19...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 12163388
DOI: 10.1016/S0002-9440(10)64219-8
PMCID: PMC1850755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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