Exploration Of 4( <i>1H</i> )-Pyridones As A Novel Family Of Potent Antimalarial Inhibitors Of The Plasmodial Cytochrome bc1

Abstract excerpt

A novel family of antimalarials based on the 4(1H)-pyridone scaffold is described. The compounds display potent antimalarial activity against Plasmodium falciparum in vitro and in vivo. Like atovaquone, 4(1H)-pyridones exert their antimalarial action by inhibiting selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III). However, despite the similar mechanism of action,...

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