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Pyrimidine Azepine Targets the Plasmodium bc 1 Complex and Displays Multistage Antimalarial Activity

7 Oct 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Malaria control and elimination efforts would benefit from the identification and validation of new malaria chemotherapeutics. Recently, a transgenic Plasmodium berghei line was used to perform a series of high-throughput in vitro screens for new antimalarials acting against the parasite sexual stages. The screens identified pyrimidine azepine chemotypes with...

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PMID: 39483245
DOI: 10.1021/jacsau.4c00674

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