Article
Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster.
PloS one - 1 Jan 2012
Beaver Laura M, Klichko Vladimir I, Chow Eileen S, Kotwica-Rolinska Joanna, Williamson Marisa, Orr William C, Radyuk Svetlana N, Giebultowicz Jadwiga M
Abstract excerpt
Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a rich arsenal of genetic tools. Previously, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.