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Article

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

13 Nov 2006

Abstract excerpt

We initially identified lens epithelium-derived growth factor/p75 (LEDGF/p75) as a binding partner of human immunodeficiency virus type 1 (HIV-1) integrase. To investigate the role of LEDGF/p75 in HIV replication and its potential as a new antiviral target, we stably overexpressed two different fragments containing the integrase binding domain (IBD) of LEDGF/p75 fused to enhanced green fluorescent protein (eGFP)....

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Identifiers

PMID: 16987986
DOI: 10.1128/jvi.00801-06

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Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus ReplicationPMID 16987986Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

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The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapySemantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZSemantic proximity Read ↗

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75Semantic proximity Read ↗

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

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Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1ReplicationSemantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 IntegraseSemantic proximity Read ↗

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV InfectionSemantic proximity Read ↗

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