Article
Elongation factor G-induced structural change in helix 34 of 16S rRNA related to translocation on the ribosome.
RNA (New York, N.Y.) - 1 Dec 2001
Matassova A B, Rodnina M V, Wintermeyer W
Abstract excerpt
During the translocation step of the elongation cycle, two tRNAs together with the mRNA move synchronously and rapidly on the ribosome. The movement is catalyzed by the binding of elongation factor G (EF-G) and driven by GTP hydrolysis. Here we study structural changes of the ribosome related to EF-G binding and translocation by monitoring the accessibility of ribosomal RNA (rRNA) for chemical modification by...
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