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Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: Association with progression of multiple sclerosis.

Neuroscience research - 1 Jul 2016

Saigoh Kazumasa, Yoshimura Satoshi, Izumikawa Tomomi, Miyata Shinji, Tabara Yasuharu, Matsushita Takuya, Miki Tetsuro, Miyamoto Katsuichi, Hirano Makito, Kitagawa Hiroshi, Kira Jun-Ichi, Kusunoki Susumu

Abstract excerpt

Chondroitin sulfate proteoglycans (CSPGs) are a constituent of the matrix of the central nervous system (CNS), likely participating as regulatory molecules in the process of demyelination, remyelination, axonal degeneration and regeneration in the CNS. ChGn-1 is a key enzyme for production of CSPGs and knock-out mice of this gene showed better recovery from spinal cord injury. We hypothesized that the clinical...

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PMID: 26806424
DOI: 10.1016/j.neures.2016.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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