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Article

Regulation of xylosyltransferase I gene expression by interleukin 1β in human primary chondrocyte cells: mechanism and impact on proteoglycan synthesis.

The Journal of biological chemistry - 18 Jan 2013

Khair Mostafa, Bourhim Mustapha, Barré Lydia, Li Dong, Netter Patrick, Magdalou Jacques, Fournel-Gigleux Sylvie, Ouzzine Mohamed

Abstract excerpt

Xylosyltransferase I (XT-I) is an essential enzyme of proteoglycan (PG) biosynthesis pathway catalyzing the initial and rate-limiting step in glycosaminoglycan chain assembly. It plays a critical role in the regulation of PG synthesis in cartilage; however, little is known about underlying mechan...

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Identifiers

PMID: 23223231
DOI: 10.1074/jbc.M112.419887
PMCID: PMC3548487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23223231-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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