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Article

Intracellular NAD<sup>+</sup>depletion induces autophagic death in multiple myeloma cells

5 Dec 2012

Abstract excerpt

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by the proliferation of plasma cells in the bone marrow. Despite recent therapeutic advances, MM remains an incurable disease. Therefore, research has focused on defining new aspects in MM biology that can be therapeutically targeted. Compelling evidence suggests that malignant cells have a higher nicotinamide adenine dinucleotide (NAD+) turnover...

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PMID: 23221771
DOI: 10.4161/auto.22866

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