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Article

Gemin5 promotes IRES interaction and translation control through its C-terminal region

5 Dec 2012

Abstract excerpt

Gene expression control largely depends on ribonucleoprotein complexes regulating mRNA translation. Initiation of translation in mRNAs that overcome cap-dependent translation inhibition is often driven by internal ribosome entry site (IRES) elements, whose activity is regulated by multifunctional RNA-binding factors. Here we show that Gemin5 interacts preferentially with a specific domain of a viral IRES...

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PMID: 23221641
DOI: 10.1093/nar/gks1212

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