Impact of Gemin5 in protein synthesis: phosphoresidues of the dimerization domain regulate ribosome binding.

Abstract excerpt

RNA-binding proteins are involved in all steps of gene expression. Their malfunction has important consequences for cell growth through dysregulation of protein synthesis events leading to cancer. Gemin5 is a predominantly cytoplasmic protein involved in spliceosome assembly and gene expression reprogramming. The protein is phosphorylated at multiple sites, although the role of the individual phosphorylated...

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