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Article

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk

10 Dec 2012

Abstract excerpt

Neurofibromatosis type 1 (NF1) predisposes individuals to the development of juvenile myelomonocytic leukemia (JMML), a fatal myeloproliferative disease (MPD). In genetically engineered murine models, nullizygosity of Nf1, a tumor suppressor gene that encodes a Ras-GTPase-activating protein, results in hyperactivity of Raf/Mek/Erk in hematopoietic stem and progenitor cells (HSPCs). Activated Erk1/2 phosphorylate...

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PMID: 23221339
DOI: 10.1172/jci66167

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