Article
The protective role of yeast cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p).
FEBS letters - 16 Jan 2013
Pereira Helena, Azevedo Flávio, Rego António, Sousa Maria João, Chaves Susana R, Côrte-Real Manuela
Abstract excerpt
We have previously shown that the yeast Cathepsin D (CatD) Pep4p translocates from the vacuole to the cytosol during acetic acid-induced apoptosis and is required for efficient mitochondrial degradation, though its specific role in this process is still elusive. Here, we show that the protective role of Pep4p in acetic acid-induced apoptosis depends on its catalytic activity and is independent of the yeast...
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