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Article

Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death.

Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011

Jain Prashant, Luo Zhao-Qing, Blanke Steven R

Abstract excerpt

A number of pathogenic bacteria target mitochondria to modulate the host's apoptotic machinery. Studies here revealed that infection with the human gastric pathogen Helicobacter pylori disrupts the morphological dynamics of mitochondria as a mechanism to induce host cell death. The vacuolating cytotoxin A (VacA) is both essential and sufficient for inducing mitochondrial network fragmentation through the...

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Identifiers

PMID: 21903925
DOI: 10.1073/pnas.1105175108
PMCID: PMC3179038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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