[Study on the genotoxicity of cefuroxime lactone--an impurity substance in antibiotics].

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Article

[Study on the genotoxicity of cefuroxime lactone--an impurity substance in antibiotics].

Wei sheng yan jiu = Journal of hygiene research - 1 Sept 2012

Cui Jie, Zhang Zunzhen, Ran Yun, Zhao Wei, Kang Xiaoxi, Deng Wenwen

Abstract excerpt

OBJECTIVE: To study the genotoxicity of cefuroxime lactone, a kind of impurity in cefuroxime sodium, and to provide experimental basis for the toxicological safety evaluation of cefuroxime sodium. METHODS: A set of efficient and convenient genetic toxicity tests were used to evaluate the genotoxicity of cefuroxime lactone, focusing on gene mutation, chromosomal aberration, DNA damage and repair. RESULTS: (1) Ames...

Topics

Animals
Anti-Bacterial Agents
Cefuroxime
Chromosome Aberrations
Comet Assay
Cricetinae
Cricetulus
Drug Contamination
Lactones
Mice
Micronucleus Tests
Mutagenicity Tests
Mutation
Salmonella typhimurium

Source

Open in PubMed

Identifiers

PMID: 23213682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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