Article
[Study on the genotoxicity of cefuroxime lactone--an impurity substance in antibiotics].
Wei sheng yan jiu = Journal of hygiene research - 1 Sept 2012
Cui Jie, Zhang Zunzhen, Ran Yun, Zhao Wei, Kang Xiaoxi, Deng Wenwen
Abstract excerpt
OBJECTIVE: To study the genotoxicity of cefuroxime lactone, a kind of impurity in cefuroxime sodium, and to provide experimental basis for the toxicological safety evaluation of cefuroxime sodium. METHODS: A set of efficient and convenient genetic toxicity tests were used to evaluate the genotoxicity of cefuroxime lactone, focusing on gene mutation, chromosomal aberration, DNA damage and repair. RESULTS: (1) Ames...
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