Article
In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin.
Toxicology mechanisms and methods - 1 Apr 2012
Zhu Qingfen, Li Tao, Li Jun, Guo Ming, Wang Weijian, Zhang Xiumei
Abstract excerpt
Impurities in drug substances and drug products generally do not have beneficial effects and may impose a risk without associated benefit. Levofloxacin n-oxide is an impurity isolated from levofloxacin. However there is insufficient toxic information about levofloxacin n-oxide. This study investigates the genotoxicity of this impurity by in silico and in vitro methods. We used Derek, a commercial...
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