Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition.

European journal of immunology - 1 Mar 2013

Khan Adnan, Fu Hongmei, Tan Lee Aun, Harper Jennifer E, Beutelspacher Sven C, Larkin Daniel F P, Lombardi Giovanna, McClure Myra O, George Andrew J T

Abstract excerpt

Dendritic cell (DC) modification is a potential strategy to induce clinical transplantation tolerance. We compared two DC modification strategies to inhibit allogeneic T-cell proliferation. In the first strategy, murine DCs were transduced with a lentiviral vector expressing CTLA4-KDEL, a fusion protein that prevents surface CD80/86 expression by retaining the co-stimulatory molecules within the ER. In the second...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Clonal Anergy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corneal Transplantation

Share to Graft Survival

Share to Immunomodulation

Share to Lentivirus

Share to Protein Sorting Signals

Share to Transplantation Tolerance

Source

Open in PubMed Open full text

Identifiers

PMID: 23212959
DOI: 10.1002/eji.201242914
PMCID: PMC3615172

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition.PMID 23212959Read ↗

Transplantation tolerance through the modulation of dendritic cellsSemantic proximity Read ↗

Tolerogenic dendritic cells suppress murine corneal allograft rejection by modulating CD28/CTLA-4 expression on regulatory T cells.Semantic proximity Read ↗

Phenotypic analysis of oral tolerance to alloantigens: evidence that the indirect pathway of antigen presentation is involved.Semantic proximity Read ↗

Aspirin and the induction of tolerance by dendritic cells.Semantic proximity Read ↗

DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties.Semantic proximity Read ↗

Exogenous IL-10 induces corneal transplantation immune tolerance by a mechanism associated with the altered Th1/Th2 cytokine ratio and the increased expression of TGF-β.Semantic proximity Read ↗

Alternative Immunomodulatory Strategies for Xenotransplantation: CD80/CD86-CTLA4 Pathway-Modified Immature Dendritic Cells Promote Xenograft SurvivalSemantic proximity Read ↗

Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation.Semantic proximity Read ↗

A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival.Semantic proximity Read ↗

Pharmacological manipulation of dendritic cells in the pursuit of transplantation tolerance.Semantic proximity Read ↗

Immune tolerance of skin allograft transplantation induced by immature dendritic cells of a third party carrying donor antigens in mice.Semantic proximity Read ↗

Alloantigen-specific T-cell hyporesponsiveness induced by dnIKK2 gene-transfected recipient immature dendritic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.