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Article

Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation.

JCI insight - 22 Oct 2024

Blanco Tomás, Nakagawa Hayate, Musayeva Aytan, Krauthammer Mark, Singh Rohan Bir, Narimatsu Akitomo, Ge Hongyan, Shoushtari Sara I, Dana Reza

Abstract excerpt

After transplantation, Th1-mediated immune rejection is the predominant cause of graft failure. Th1 cell sensitization occurs through complex and context-dependent interaction among antigen-presenting cell subsets, particularly CD11b+ DCs (DC2) and CD103+ DCs (DC1). This interaction necessitates further investigation in the context of transplant immunity. We used well-established preclinical models of corneal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39235864
DOI: 10.1172/jci.insight.182469
PMCID: PMC11530131

Genes

CD4
CD80

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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