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Article

Implication of genetic variation at the promoter and exon1 of UGT1A1 in occurrence of cholelithiasis in Tunisia.

Annales de biologie clinique - 1 Jan 2000

Chaouch Leila, Said Yossra, Moumni Imen, Mahjoubi Imen, Chaabene Arij Ben, Darragi Imen, Ghanem Abderraouf, Abbes Salem

Abstract excerpt

Bilirubin is conjugated with glucoronic acid in the liver by UDP-glucuronosyltransferase 1A1 (UGT1A1). Polymorphisms at the promoter region or exon1 of UGT1A1 gene result in unconjugated hyperbilirubinemia and could be at the origin of gallstone formation. The purpose of this study is to determine whether polymorphisms in the promoter area and exon 1 of UGT1A1 can be considered as a risk factor for lithogenesis....

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Identifiers

PMID: 23207817
DOI: 10.1684/abc.2012.0743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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