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Article

LDL density and oxidation are modulated by PON1 promoter genotype in patients with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Cagnin Annachiara, Leon Alberta, Vianello Daniela, Colavito Davide, Favaretto Silvia, Zarantonello Giulia, Stecca Anna, Ermani Mario, Zambon Alberto

Abstract excerpt

Cholesterol metabolism alteration is a hot topic in the field of Alzheimer's disease (AD). However, data on plasma lipoproteins cholesterol distribution and oxidation in AD and their possible genetic determinants are lacking. The paraoxonase-1 (PON1) gene -107C/T promoter polymorphisms have been found associated with AD. One of the fundamental functions of PON1 enzyme is the inhibition of low-density lipoproteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryldialkylphosphatase

Share to Centrifugation, Density Gradient

Share to Lipoproteins, LDL

Share to Neural Pathways

Share to Oxidative Stress

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 23207490
DOI: 10.3233/JAD-121717

Genes

PON1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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