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Article

A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.

Cancer research - 1 Dec 2012

Nikolaev Sergey I, Sotiriou Sotirios K, Pateras Ioannis S, Santoni Federico, Sougioultzis Stavros, Edgren Henrik, Almusa Henrikki, Robyr Daniel, Guipponi Michel, Saarela Janna, Gorgoulis Vassilis G, Antonarakis Stylianos E, Halazonetis Thanos D

Abstract excerpt

Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer. In particular, replication stress can explain the high prevalence of focal genomic deletions mapping within very large genes in human tumors. However, the origin of single-nucleotide substitutions (SNS) in nonfamilial cancers is strongly debated. Some argue that cancers have a mutator phenotype, whereas others argue that...

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Source

Identifiers

PMID: 23204322
DOI: 10.1158/0008-5472.CAN-12-3869

Genes

APC
BRAF
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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