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Article

Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype.

Occupational and environmental medicine - 1 Oct 2011

Dillon Madeline A, Harris Bradford, Hernandez Michelle L, Zou Baiming, Reed William, Bromberg Philip A, Devlin Robert B, Diaz-Sanchez David, Kleeberger Steven, Zhou Haibo, Lay John C, Alexis Neil E, Peden David B

Abstract excerpt

OBJECTIVE: To determine if the GSTM1 null genotype is a risk factor for increased inflammatory response to inhaled endotoxin. METHODS: 35 volunteers who had undergone inhalation challenge with a 20 000 endotoxin unit dose of Clinical Center Reference Endotoxin (CCRE) were genotyped for the GSTM1 null polymorphism. Parameters of airway and systemic inflammation observed before and after challenge were compared in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 21441173
DOI: 10.1136/oem.2010.061747
PMCID: PMC3808962

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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