Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

6 Nov 2012

Abstract excerpt

There are no currently approved treatments for filovirus infections. In this study we report the discovery process which led to the development of antisense Phosphorodiamidate Morpholino Oligomers (PMOs) AVI-6002 (composed of AVI-7357 and AVI-7539) and AVI-6003 (composed of AVI-7287 and AVI-7288) targeting Ebola virus and Marburg virus respectively. The discovery process involved identification of optimal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Outbreaks Research
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23202506
DOI: 10.3390/v4112806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus InfectionsPMID 23202506Read ↗

Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino OligomersSemantic proximity Read ↗

VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in MiceSemantic proximity Read ↗

A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects Rhesus Monkeys against Lethal Ebola Virus InfectionSemantic proximity Read ↗

Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccineSemantic proximity Read ↗

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomersSemantic proximity Read ↗

Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics.Semantic proximity Read ↗

Current status of small molecule drug development for Ebola virus and other filovirusesSemantic proximity Read ↗

New pharmacological strategies to fight enveloped virusesSemantic proximity Read ↗

Antisense Oligonucleotide-Based Therapy of Viral InfectionsSemantic proximity Read ↗

Novel approaches in anti-arenaviral drug developmentSemantic proximity Read ↗

A panel of biologically contained orthoebolaviruses for the screening of broad-spectrum antiviralsSemantic proximity Read ↗

Marburg Virus Reverse Genetics SystemsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.