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Article

VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice

22 Feb 2006

Abstract excerpt

Phosphorodiamidate morpholino oligomers (PMO) are a class of uncharged single-stranded DNA analogs modified such that each subunit includes a phosphorodiamidate linkage and morpholine ring. PMO antisense agents have been reported to effectively interfere with the replication of several positive-strand RNA viruses in cell culture. The filoviruses, Marburg virus and Ebola virus (EBOV), are negative-strand RNA...

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PMID: 16495261
DOI: 10.1128/aac.50.3.984-993.2006

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