Article
Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics.
mBio - 20 Jan 2015
Kugelman Jeffrey R, Sanchez-Lockhart Mariano, Andersen Kristian G, Gire Stephen, Park Daniel J, Sealfon Rachel, Lin Aaron E, Wohl Shirlee, Sabeti Pardis C, Kuhn Jens H, Palacios Gustavo F
Abstract excerpt
Until recently, Ebola virus (EBOV) was a rarely encountered human pathogen that caused disease among small populations with extraordinarily high lethality. At the end of 2013, EBOV initiated an unprecedented disease outbreak in West Africa that is still ongoing and has already caused thousands of deaths. Recent studies revealed the genomic changes this particular EBOV variant undergoes over time during...
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