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Article

Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants.

BMC immunology - 27 Jan 2009

Barreto Marta, Ferreira Ricardo C, Lourenço Lara, Moraes-Fontes Maria F, Santos Eugénia, Alves Miguel, Carvalho Cláudia, Martins Berta, Andreia Rita, Viana João F, Vasconcelos Carlos, Mota-Vieira Luísa, Ferreira Carlos, Demengeot Jocelyne, Vicente Astrid M

Abstract excerpt

BACKGROUND: CD4+CD25+ regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent...

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

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Source

Open in PubMed Open full text

Identifiers

PMID: 19173720
DOI: 10.1186/1471-2172-10-5
PMCID: PMC2656467

Genes

FOXP3
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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