Article
VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.
Antioxidants & redox signaling - 10 Aug 2013
Tao Bei-Bei, Liu Shu-Yuan, Zhang Cai-Cai, Fu Wei, Cai Wen-Jie, Wang Yi, Shen Qing, Wang Ming-Jie, Chen Ying, Zhang Li-Jia, Zhu Yi-Zhun, Zhu Yi-Chun
Abstract excerpt
AIMS: The potential receptor for hydrogen sulfide (H2S) remains unknown. RESULTS: H2S could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a small interfering RNA (siRNA)-mediated knockdown of VEGFR2 inhibited H2S-induced migration of human vascular endothelial cells. H2S promoted angiogenesis in Matrigel plug assay in mice and this effect was attenuated by a VEGF receptor...
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