Article
What's new in non-small cell lung cancer for pathologists: the importance of accurate subtyping, EGFR mutations and ALK rearrangements.
Pathology - 1 Feb 2011
Cooper Wendy A, O'toole Sandra, Boyer Michael, Horvath Lisa, Mahar Annabelle
Abstract excerpt
In the past, the only critical point of distinction in the pathological diagnosis of lung cancer was between small cell and non-small cell lung cancer (NSCLC). The emergence of new targeted therapies and clinical trials demonstrating differing efficacy and toxicity of treatments according to specific histological subtypes of NSCLC, has resulted in an increasing need for improvements in pathological diagnosis....
Topics
- Adenocarcinoma
- Algorithms
- Anaplastic Lymphoma Kinase
- Biomarkers, Tumor
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Diagnosis, Differential
- Gene Rearrangement
- Genes, erbB-1
- Humans
- Lung Neoplasms
- Mutation
- Protein-Tyrosine Kinases
- Receptor Protein-Tyrosine Kinases
- World Health Organization