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Article

Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA.

Journal of virology - 1 Sept 1990

Niesters H G, Strauss J H

Abstract excerpt

We have constructed 24 deletion mutants which contain deletions of from 1 to 15 nucleotides in the 5' nontranslated region of Sindbis virus RNA and tested the effect of these mutations on virus replication. The results showed that the first 44 nucleotides, which are capable of forming a hairpin structure, are important for virus replication, as all deletions tested in this region were either lethal or resulted in...

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Identifiers

PMID: 2384916
DOI: 10.1128/JVI.64.9.4162-4168.1990
PMCID: PMC247880

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