Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA.

doi:10.1128/JVI.64.9.4162-4168.1990

Back to search

Article

Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA.

Journal of virology - 1 Sept 1990

Niesters H G, Strauss J H

Abstract excerpt

We have constructed 24 deletion mutants which contain deletions of from 1 to 15 nucleotides in the 5' nontranslated region of Sindbis virus RNA and tested the effect of these mutations on virus replication. The results showed that the first 44 nucleotides, which are capable of forming a hairpin s...

Topics

Aedes
Animals
Base Sequence
Cell Line
Chick Embryo
Chromosome Deletion
Fibroblasts
Models, Molecular
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Protein Biosynthesis
RNA, Viral
Sindbis Virus
Temperature

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.