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Article

Mutagenesis of the 3' nontranslated region of Sindbis virus RNA.

Journal of virology - 1 Apr 1990

Kuhn R J, Hong Z, Strauss J H

Abstract excerpt

A cDNA clone from which infectious RNA can be transcribed was used to construct 42 site-specific mutations in the 3' nontranslated region of the Sindbis virus genome. The majority of these mutations were made in the 3'-terminal 19-nucleotide conserved sequence element and consisted of single nucleotide substitutions or of small (1 to 8) nucleotide deletions. An attempt was made to recover mutant viruses after...

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Identifiers

PMID: 2319643
DOI: 10.1128/JVI.64.4.1465-1476.1990
PMCID: PMC249280

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