Article
Specificity of resistance to dengue virus isolates is associated with genotypes of the mosquito antiviral gene Dicer-2.
Proceedings. Biological sciences - 22 Jan 2013
Lambrechts Louis, Quillery Elsa, Noël Valérie, Richardson Jason H, Jarman Richard G, Scott Thomas W, Chevillon Christine
Abstract excerpt
In contrast to the prevailing view that invertebrate immunity relies on broad-spectrum recognition and effector mechanisms, intrinsic genetic compatibility between invertebrate hosts and their pathogens is often highly specific in nature. Solving this puzzle requires a better understanding of the molecular basis underlying observed patterns of invertebrate host-pathogen genetic specificity, broadly referred to as...
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