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Article

Intraspecific genetic variation in host vigour, viral load and disease tolerance during Drosophila C virus infection.

Open biology - 1 Mar 2023

Kutzer Megan A M, Gupta Vanika, Neophytou Kyriaki, Doublet Vincent, Monteith Katy M, Vale Pedro F

Abstract excerpt

Genetic variation for resistance and disease tolerance has been described in a range of species. In Drosophila melanogaster, genetic variation in mortality following systemic Drosophila C virus (DCV) infection is driven by large-effect polymorphisms in the restriction factor pastrel (pst). However, it is unclear if pst contributes to disease tolerance. We investigated systemic DCV challenges spanning nine orders...

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PMID: 36854375
DOI: 10.1098/rsob.230025
PMCID: PMC9974301

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