Article
GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.
Pharmacogenetics and genomics - 1 Jun 2010
Choudhry Shweta, Que Loretta G, Yang Zhonghui, Liu Limin, Eng Celeste, Kim Sung O, Kumar Gunjan, Thyne Shannon, Chapela Rocio, Rodriguez-Santana Jose R, Rodriguez-Cintron William, Avila Pedro C, Stamler Jonathan S, Burchard Esteban G
Abstract excerpt
BACKGROUND: Short-acting inhaled beta2-agonists such as albuterol are used for bronchodilation and are the mainstay of asthma treatment worldwide. There is significant variation in bronchodilator responsiveness to albuterol not only between individuals but also across racial/ethnic groups. The beta2-adrenergic receptor (beta2AR) is the target for beta2-agonist drugs. The enzyme, S-nitrosoglutathione reductase...
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