Plasma levels of C1- inhibitor complexes and cleaved C1- inhibitor in patients with hereditary angioneurotic edema.

doi:10.1172/JCI114555

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Article

Plasma levels of C1- inhibitor complexes and cleaved C1- inhibitor in patients with hereditary angioneurotic edema.

The Journal of clinical investigation - 1 Apr 1990

Cugno M, Nuijens J, Hack E, Eerenberg A, Frangi D, Agostoni A, Cicardi M

Abstract excerpt

C1- inhibitor (C1(-)-Inh) catabolism in plasma of patients with hereditary angioneurotic edema (HANE) was assessed by measuring the complexes formed by C1(-)-Inh with its target proteases (C1-s, Factor XIIa, and kallikrein) and a modified (cleaved) inactive form of C1(-)-Inh (iC1(-)-Inh). This st...

Topics

Adolescent
Adult
Aged
Angioedema
Complement C1 Inactivator Proteins
Electrophoresis, Polyacrylamide Gel
Female
Humans
Male
Middle Aged
Molecular Weight
Mutation

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