Article
High-molecular-weight kininogen cleavage correlates with disease states in the bradykinin-mediated angioedema due to hereditary C1-inhibitor deficiency.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2014
Suffritti C, Zanichelli A, Maggioni L, Bonanni E, Cugno M, Cicardi M
Abstract excerpt
BACKGROUND: The inherited deficiency of C1-inhibitor (C1-INH), which can be quantitative (type I) or qualitative (type II), is characterized by recurrent attacks of oedema, and it is known as hereditary angioedema due to C1-INH deficiency (HAE-C1-INH). The frequency of symptoms varies widely among patients and in the same patient during life. OBJECTIVE: To identify laboratory markers of disease severity in...
Topics
- Adolescent
- Adult
- Aged
- Angioedemas, Hereditary
- Bradykinin
- Case-Control Studies
- Chemoprevention
- Child
- Complement C1 Inhibitor Protein
- Complement C1q
- Complement C4
- Disease Progression
- Female