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Article

Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.

PloS one - 1 Jan 2012

Tervaniemi Mari H, Siitonen H Annika, Söderhäll Cilla, Minhas Gurinder, Vuola Jyrki, Tiala Inkeri, Sormunen Raija, Samuelsson Lena, Suomela Sari, Kere Juha, Elomaa Outi

Abstract excerpt

CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC. Although its expression pattern in psoriatic skin differs from healthy skin and its overexpression influences cell proliferation in transgenic mice, its role as a psoriasis effector gene has remained unsettled. The 5'-region of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23189171
DOI: 10.1371/journal.pone.0049920
PMCID: PMC3506594

Genes

CCHCR1
STAT3
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.PMID 23189171Read ↗

Cell cycle regulation of the psoriasis associated gene <i>CCHCR1</i> by transcription factor E2F1Semantic proximity Read ↗

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