Article
Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus.
Annals of human genetics - 1 Nov 2004
Giardina E, Capon F, De Rosa M C, Mango R, Zambruno G, Orecchia A, Chimenti S, Giardina B, Novelli G
Abstract excerpt
Psoriasis is a chronic inflammatory disease of the skin with both genetic and environmental risk factors. Non-parametric linkage analyses have mapped many susceptibility loci on different chromosomes. We mapped one of these loci, PSORS4, on human chromosome 1q21. Using the linkage disequilibrium approach, we refined the critical region to a specific genomic interval of about 100 Kb which contains only the...
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