Article
Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.
The Journal of biological chemistry - 11 Jan 2013
Mochizuki Yasuhiro, Ohashi Riuko, Kawamura Takeshi, Iwanari Hiroko, Kodama Tatsuhiko, Naito Makoto, Hamakubo Takao
Abstract excerpt
A large family of myotubularin phosphatases dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, which are known to play important roles in vesicular trafficking and autophagy. The family is composed of 16 members, and understanding their regulatory mechanisms is important to understand their functions and related genetic diseases. We prepared anti-myotubularin-related...
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