Article

The role of Rab proteins in phosphatidylinositol 3,5-bisphosphate-mediated cellular traffic and signalling

2020-01-01

Abstract excerpt

Patients suffering from the peripheral neuropathy Charcot-Marie-Tooth type 4B (CMT4B) present mutations in three proteins which belong to the same enzymatic complex acting to dephosphorylate the phosphoinositide lipids phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Either of the catalytically inactive myotubularin-related proteins (MTMR) 5 and 13 forms a complex with...

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Literature Corpus work: 70148048-f026-574f-99f5-aabf30dbc30a
DOI: 10.17638/03096506

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