Enhanced resistance to cefotaxime and imipenem associated with outer membrane protein alterations in Enterobacter aerogenes.

doi:10.1093/jac/25.1.49

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Article

Enhanced resistance to cefotaxime and imipenem associated with outer membrane protein alterations in Enterobacter aerogenes.

The Journal of antimicrobial chemotherapy - 1 Jan 1990

Hopkins J M, Towner K J

Abstract excerpt

Mutants exhibiting enhanced resistance to cefotaxime and imipenem were selected by plating a strain of Enterobacter aerogenes, which already produced chromosomal beta-lactamase constitutively, on to varying concentrations of different beta-lactam antibiotics. Frequencies of mutation varied from 1...

Topics

Cefotaxime
Cell Membrane Permeability
Drug Resistance, Microbial
Enterobacter
Imipenem
Membrane Proteins
Mutation
beta-Lactamases

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