Article
Antibiotic susceptibility of Escherichia coli dnaK and dnaJ mutants.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2000
Wolska K I, Bugajska E, Jurkiewicz D, Kuć M, Jóźwik A
Abstract excerpt
The role of two chaperone proteins, DnaK and the cooperating factor DnaJ, in Escherichia coli antibiotic susceptibility to three antibiotics (a beta-lactam, chloramphenicol, tetracycline) has been studied. It was found that null dnaJ and dnaKdnaJ mutants are impaired in the functions leading to antibiotic susceptibility. The secretion of beta-lactamase to the periplasmic space is diminished in both mutants, and...
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