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Article

Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins.

Antimicrobial agents and chemotherapy - 1 Jun 1991

Raimondi A, Traverso A, Nikaido H

Abstract excerpt

Carbapenems such as imipenem and meropenem are not rapidly hydrolyzed by commonly occurring beta-lactamases. Nevertheless, it was possible, by mutagenesis and selection, to isolate mutant strains of Enterobacter cloacae and Proteus rettgeri that are highly resistant to meropenem and imipenem. Two alterations were noted in the E. cloacae mutants. First, the mutant strains appeared to be strongly derepressed in the...

Topics

Bacterial Outer Membrane Proteins
Drug Resistance, Microbial
Electrophoresis
Enterobacter
Imipenem
Liposomes
Meropenem
Mutation
Permeability
Phenotype
Porins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteus

Thienamycins

beta-Lactamases

Source

Open in PubMed Open full text

Identifiers

PMID: 1656855
DOI: 10.1128/AAC.35.6.1174
PMCID: PMC284306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656855-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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