Consecutive mutations leading to the emergence in vivo of imipenem resistance in a clinical strain of Enterobacter aerogenes.

doi:10.1099/00222615-40-6-403

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Article

Consecutive mutations leading to the emergence in vivo of imipenem resistance in a clinical strain of Enterobacter aerogenes.

Journal of medical microbiology - 1 Jun 1994

Tzouvelekis L S, Tzelepi E, Kaufmann M E, Mentis A F

Abstract excerpt

Three consecutive isolates of Enterobacter aerogenes were obtained from the blood cultures of a hospitalised patient who was receiving antibiotic therapy. The initial isolate possessed an inducible cephalosporinase and was susceptible to third-generation cephalosporins. After ceftazidime treatmen...

Topics

Aged
Bacterial Outer Membrane Proteins
Cell Membrane Permeability
Cephalosporins
Drug Resistance, Microbial
Enterobacter
Enterobacteriaceae Infections
Humans
Imipenem
Mutation
beta-Lactamases

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