Article
Activity of cefepime and other beta-lactam antibiotics against permeability mutants of Escherichia coli and Klebsiella pneumoniae.
The Journal of antimicrobial chemotherapy - 1 Nov 1993
Chen H Y, Livermore D M
Abstract excerpt
Permeability mutants were obtained, under selection pressure with cefoxitin, from five strains each of Escherichia coli and Klebsiella pneumoniae. Most mutants showed alterations to their outer membrane protein profiles. In general, the porins OmpC and F were lost from E. coli mutants, and one or...
Topics
- Anti-Bacterial Agents
- Cefepime
- Cell Membrane Permeability
- Cephalosporins
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Klebsiella pneumoniae
- Microbial Sensitivity Tests
- Mutation
- Porins