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Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression

30 Nov 2012

Abstract excerpt

Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between MMPs and TIMPs is associated with various diseased states. Among TIMPs, TIMP-1, a 184-residue...

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PMID: 23187000
DOI: 10.5483/bmbrep.2012.45.11.233

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