Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.

doi:10.1158/1078-0432.CCR-12-1842

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Article

Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2013

Nardi Valentina, Sadow Peter M, Juric Dejan, Zhao Dave, Cosper Arjola K, Bergethon Kristin, Scialabba Vanessa L, Batten Julie M, Borger Darrell R, Iafrate Anthony John, Heist Rebecca S, Lawrence Donald P, Flaherty Keith T, Bendell Johanna C, Deschler Daniel, Li Yi, Wirth Lori J, Dias-Santagata Dora

Abstract excerpt

PURPOSE: Salivary duct carcinomas (SDC) are a rare and aggressive subtype of salivary gland cancers for which cytotoxic chemotherapy has limited efficacy. We investigated whether genotyping analysis could detect novel tumor-specific mutations that would help direct SDC patient treatment using targeted agents. EXPERIMENTAL DESIGN: We genotyped 27 SDC archival specimens from patients followed at Massachusetts...

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PMID: 23186780
DOI: 10.1158/1078-0432.CCR-12-1842

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BRAF

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