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Article

Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling

14 Oct 2019

Abstract excerpt

Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor (AR), which could be targeted in a subset of patients, but the presence of AR splice variant-7 (AR-V7) in some SDC cases could result in resistance to anti-androgen therapy. We evaluated a...

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PMID: 31609094
DOI: 10.1002/cam4.2602

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