Article
Amplification of HER2 is a marker for global genomic instability.
BMC cancer - 14 Oct 2008
Ellsworth Rachel E, Ellsworth Darrell L, Patney Heather L, Deyarmin Brenda, Love Brad, Hooke Jeffrey A, Shriver Craig D
Abstract excerpt
BACKGROUND: Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can be influenced by other genetic changes. To assess the broader genomic implications of...
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